Calabrese Lab Publications

Norris BJ, Weaver AL, Wenning A, García PS, Calabrese RL. (2007) A central pattern generator producing alternative outputs: phase relations of leech heart motor neurons with respect to premotor synaptic input. J Neurophysiol. 98(5):2983-91. Epub 2007 Aug 29.

Norris BJ, Weaver AL, Wenning A, García PS, Calabrese RL. (2007) A central pattern generator producing alternative outputs: pattern, strength, and dynamics of premotor synaptic input to leech heart motor neurons. J Neurophysiol. 98(5):2992-3005. Epub 2007 Sep 5.

Calabrese RL. (2007) Motor networks: shifting coalitions. Curr Biol. 17:R139-41. Review.

Olypher, A.V., and Calabrese, R.L. (2007) Using constraints on neuronal activity to reveal compensatory changes in neuronal parameters. J Neurophysiol. 98: 3749-3758. [pdf]

Tobin, A.E., Van Hooser, S.D., and Calabrese, R.L. (2006) Creation and reduction of a morphologically detailed model of a leech heart interneuron. J Neurophysiol. 96:2107-2120.

Tobin, A.E. and Calabrese, R.L. (2006) Endogenous and half-center bursting in morphologically inspired models of leech heart interneurons. J Neurophysiol. 96:2089-2106.

Olypher, A.V., Cymbalyuk, G., and Calabrese, R.L. (2006) Hybrid Systems Analysis of the Control of Burst Duration by Low-Voltage-Activated Calcium Current in Leech Heart Interneurons. J Neurophysiol. 96(6):2857-2867. Epub 2006 Aug 30. [pdf]

Norris, B.J., Weaver, A.L., Morris, L.G., Wenning, A., Garcia, P.A. and Calabrese, R.L. (2006) A central pattern generator producing alternative outputs: temporal pattern of premotor activity. J Neurophysiol. 96:309-326.

Ivanov, A.I. and Calabrese, R.L. (2006) Graded inhibitory synaptic transmission between leech interneurons: assessing the roles of two kinetically distinct low-threshold Ca currents. J Neurophysiol. 96:218-234.

Ivanov, A.I. and Calabrese, R.L. (2006) Spike-mediated and graded inhibitory synaptic transmission between leech interneurons: evidence for shared release sites. J Neurophysiol. 96:235-251.

Tobin, A.E. and Calabrese, R.L. (2006) Myomodulin increases Ih and inhibits the NA/K pump to modulate bursting in leech heart interneurons. J Neurophysiol. 94:3938-3950.

Shilnikov, A., Calabrese, R.L. and Cymbalyuk, Q. (2005) Mechanism of bistability: tonic spiking and bursting in a neuron model of bistability: tonic spiking and bursting in a neuron model. Phys Rev E Stat Nonlin Soft Matter Phys. 71 May;5Pt2:056214

Kristan, W.B.,Jr., Calabrese, R.L. and Friesen, W.O. (2006) Neuronal control of leech behavior. Prog Neurobiol. 76:279-327.

Wenning A., Cymbalyuk, G.S., and Calabrese, R.L. (2004) Heartbeat Control in Leeches: I. Constriction Pattern and Neural Modulation of Blood Pressure in Intact Animals. J Neurophys. 91:382-396

Wenning A., Hill, A.A., and Calabrese, R.L. (2004) Heartbeat Control in Leeches: II. Fictive Motor Pattern. J Neurophysiol. 91:397-409

Sorensen, M., DeWeerth, S., Cymbalyuk, G.S. and Calabrese, R.L. (2004) Using a hybrid neural system to reveal regulation of neuronal network activity by an intrinsic current. J Neurosci. 24:5427-5438

Simoni, M.F., Cymbalyuk, G.S., Sorensen, M., Calabrese, R.L. and DeWeerth, S.P. (2004) A multiconductance silicon neuron with biologically matched dynamics. IEEE Trans Biomed Eng. 51:342-354

Jezzini, S.H., Hill, A.A., Kuzyk, P. and Calabrese, R.L. (2004) Detailed model of intersegmental coordination in the timing network of the leech heartbeat central pattern generator. J Neurophys. 91:958-977.

Calabrese, R.L. (2004) Neuronal networks: dissection one channel at a time. Curr Biol. 14:R154-155.

Hill, A.A., Masino, M.A., and Calabrese, R.L. (2003) Intersegmental coordination of rhythmic motor patterns. J Neurophys. 90:531-538.

Bondarenko, V.E., Cymbalyuk, G.S., Patel, G., DeWeerth S.P. and Calabrese, R.L. (2004) Bifurcation of synchronous oscillations into torus in a system of two reciprocally inhibitory silicon neurons: experimental observation and modeling. Chaos 14:995-1003.

Ivanov, A.I., and Calabrese, R.L. (2003) Modulation of Spike-Mediated Synaptic Transmission by Presynaptic Background Ca2+ in Leech Heart Interneurons. J Neurosci.22:10580-10592.

Calabrese, R.L. (2003) Behavioral choices: how neuronal networks make decisions. Curr Biol.13:R140-R142.

Cymbalyuk, G.S., Gaudry, Q., Masino, M.A., and Calabrese, R.L. Bursting in leech heart interneurons: cell autonomous and network based mechanisms. J Neurosci.22:10580-10592.

Masino, M.A., and Calabrese, R.L. (2002) A functional asymmetry in the Leech Heartbeat Timing Network is revealed by driving the network across various cycle periods. J Neurosci.22:4418-4427.

Masino, M.A., and Calabrese, R.L. (2002) Period differences between segmental oscillators produce intersegmental phase differences in the leech heartbeat timing network. J Neurophysiol.87:1603-1615.

Hill, A.A., Masino, M.A., Calabrese, R.L. (2002) Model of intersegmental coordination in the leech heartbeat neuronal network. J Neurophysiol.87:1586-1602.

Masino, M.A., and Calabrese, R.L.(2002) Phase relationships between segmentally organized oscillators in the leech heartbeat pattern generating network. J Neurophysiol.87:1572-1585.

Wenning A, Erxleben CF, Calabrese RL.(2001) Indirectly gated Cl(-)-dependent Cl(-) channels sense physiological changes of extracellular chloride in the leech. J Neurophysiol.86:1826-1838.

Hill, A.A., Lu, J., Masino, M.A., Olsen, O.H., and Calabrese, R.L. (2001) A model of a segmental oscillator in the leech heartbeat neuronal network. J Comput Neurosci.10(3):281-302.

Cymbalyuk, G.S., Calabrese, R.L. Oscillatory behaviors in pharmacologically isolated heart interneurons from the medicinal leech. Neurocomputing 32: 97-104, 2000.

Cymbalyuk, G.S., Patel, G.N., Calabrese, R.L., DeWeerth, S.P, Cohen, A.H. Modeling alternation to synchrony with inhibitory coupling: A neuromorphic VLSI approach. Neural Computation 12: 2259-2278, 2000.

Ivanov, A.I.,Calabrese, R.L. Intracellular Ca2+ dynamics during spontaneous and evoked activity of leech heart interneurons: low-threshold Ca currents and graded synaptic transmission. J. Neuroscience, 20(13): 4930-4943, 2000. [abstract]

Calabrese, R.L. Neural coordination: Taking the lead from a model. Curr Biol. 9(18): R680-683, 1999. [abstract]

Lu, J., Gramoll, S., Schmidt, J., Calabrese, R.L. Motor pattern switching in the heartbeat pattern generator of the medicinal leech: membrane properties and lack of synaptic interaction in switch interneurons. J Comp Physiol [A] 184(3):311-24, 1999. [abstract]

Calabrese, R.L. Cellular, synaptic, network, and modulatory mechanisms involved in rhythm generation. Curr. Opin. Neurobiol. 8(6): 710-717, 1998. [abstract]

Lu, J., Dalton, J.F. IV, Stokes, D.R., and Calabrese, R.L. Functional Role of Calcium Currents in Graded and Spiked-Mediated Synaptic Transmission Between Leech Heart Interneurons. J. Neurophysiol. 77, 1779-1794 (1997).

Nadim F, Calabrese RL. A slow outward current activated by FMRFamide in heart interneurons of the medicinal leech. J Neurosci. 17(11): 4461-4472, 1997. [abstract]

Marder E, Calabrese RL. Principles of rhythmic motor pattern generation. Physiol Rev. 76(3): 687-717, 1996.

Olsen, Ø.H., and Calabrese, R.L. Activation of Intrinsic and Synaptic Currents in Leech Heart Interneurons by Realistic Waveforms J. Neurosci. 16, 4958-4970, (1996).

Calabrese, RL. Oscillation in motor pattern-generating networks. Curr Opin Neurobiol. 5(6): 816-823, 1995.

Calabrese, R.L., Nadim, F., Olsen, O.H. Heartbeat control in the medicinal leech: a model system for understanding the origin, coordination, and modulation of rhythmic motor patterns. J Neurobiol. 27(3): 390-402, 1995.

Nadim, F., Olsen, Ø.H., DeSchutter, E. and Calabrese, R.L. Modeling the Leech Heartbeat Elemental Oscillator: I. Interactions of Intrinsic and Synaptic Currents, J. Computational Neuroscience, 2, 215-235 (1995).

Olsen, Ø.H., Nadim, F. and Calabrese, R.L. Modeling the Leech Heartbeat Elemental Oscillator: II. Exploring the Parameter Space, J. Computational Neuroscience, 2, 237-257 (1995).

Opdyke CA, Calabrese RL. Outward currents in heart motor neurons of the medicinal leech. J Neurophysiol. 74(6): 2524-2537, 1995.

Schmidt, J., Gramoll, S., Calabrese, R.L. Segment-specific effects of FMRFamide on membrane properties of heart interneurons in the leech. J Neurophysiol. 74(4): 1485-1497, 1995.

Wenning, A., Calabrese, R.L. An endogenous peptide modulates the activity of a sensory neurone in the leech Hirudo medicinalis. J Exp Biol. 198 ( Pt 6): 1405-1415, 1995.

Gramoll, S., Schmidt, J. and Calabrese, R.L. Switching in the activity state of an interneuron that controls the coordination of the hearts in the medicinal leech (Hirudo medicinalis). J. Experimental Biology 186: 157-171, 1994.

Simon, T.W., Schmidt, J. and Calabrese, R.L. Modulation of high-threshold transmission between heart interneurons of the medicinal leech by FMRF-NH2. J. Neurophysiology 71:454-466, 1994.

Opdyke, C.A. and Calabrese, R.L. A persistent sodium current contributes to oscillatory activity in heart interneurons of the medicinal leech. J. Comparative Physiology A 175:781-789, 1994.

Skinner, F.K., Gramoll, S., Calabrese, R.L., Kopell N. and Marder, E. Frequency control in biological half-center oscillators. From: Computation and Neural Systems, F. Eeckman and J.M. Bower, Eds. Kluwer Academic Press, Boston, MA, 1994.

DeSchutter, E., Angstadt, J.D. and Calabrese, R.L. A model of graded synaptic transmission for use in dynamic network simulations. J. Neurophysiology 69: 1225-1235, 1993.

Weimann, J.M., Marder, E., Evans, B., and Calabrese, R.L. The effects of SDRNFLRFamide and TNRNFLRFamide on the motor patterns of the stomatogastric ganglion of the crab Cancer Borealis. J. Experimental Biology 181: 1-26, 1993.

Wenning, A., Cahill, M.A., Hoeger, U. and Calabrese, R.L. Sensory and neurosecretory innervation of leech nephridia is accomplished by a single neuron containing FMRFamide. J. Experimental Biology 182: 81-96, 1993.

Calabrese RL, De Schutter E. Motor-pattern-generating networks in invertebrates: modeling our way toward understanding. Trends Neurosci. 15(11): 439-445, 1992.

Simon, T.W., Opdyke, C.A., and Calabrese, R.L. Modulatory effects of FMRF-NH2 on outward currents and oscillatory activity in heart interneurons of the medicinal leech. J. Neuroscience 12: 525-537, 1992.

Thompson, K.J. and Calabrese, R.L. FMRFamide effects on membrane properties of heart cells isolated from the leech, Hirudo medicinalis. J. Neurophysiology 67: 280-291, 1992.

Schmidt, J. and Calabrese, R.L. Evidence that acetylcholine is an inhibitory transmitter of heart interneurons in the leech. J. Experimental Biology 171: 329-347, 1992.

Angstadt, J.D. and Calabrese, R.L. Calcium currents and graded synaptic transmission between heart interneurons of the leech. J. Neurosci. 11: 746-759, 1991.

Wenning, A. and Calabrese, R.L. Mechanism of Cl- sensitivity in internal ion receptors of the leech: an inward current gated off my Cl- in nephridial nerve cells. J. Comp. Physiol. A, 168: 53-61, 1991.

Evans, B.D., Pohl, J. Karsonis, N.A. and Calabrese, R.L. Identification of RFamide neuropeptides in the medicinal leech. Peptides 12: 897-908, 1991.

Norris, B.J. and Calabrese, R.L. Action of FMRFamide on longitudinal muscle of the leech, Hirudo medicinalis. J. Comp. Physiol. A, 167: 211-224, 1990.

Arbas. E.A. and Calabrese, R.L. Leydig neuron activity modulates heartbeat in the medicinal leech. J. Comp. Physiol. A, 167: 665-671, 1990.

Calabrese, R.L. and Arbas, E.W. Central and peripheral oscillators generate heartbeat in the leech, Hirudo medicinalis. From: Cellular and Neuronal Oscillators, J.W. Jacklet, Eds. Marcel Dekker, New York, 1989.

Angstadt, J.D. and Calabrese, R.L. A hyperpolarization-activated inward current in heart interneurons of the medicinal leech. J. Neurosci. 9: 2846-2857, 1989.

Calabrese, R.L., Angstadt, J.D. and Arbas, E.A. A neural oscillator based on reciprocal inhibition. From: Perspectives in Neural Systems and Behavior, pp. 33-50, T.J. Carew and D. Kelley, Eds. Alan R. Liss, New York, 1989.

Calabrese, R.L. Modulation of muscle and neuromuscular junctions in invertebrates. SINS 1: 25-34, 1989.

Evans, B.D. and Calabrese, R.L. SCP-like immunoreactivity and its colocalization with FMRFamide-like immunoreactivity in the central nervous system of the leech Hirudo medicinalis. Cell and Tissue Res. 257: 187-199, 1989.

Li, C., and Calabrese, R.L. FMRFamide-like substances in the leech: III. Biochemical characterization and physiological effects. J. Neurosci. 7: 595-603, 1987.

Arbas, E.A. and Calabrese, R.L. Ionic conductances underlying the activity of interneurons that control heartbeat in the medicinal leech. J. Neurosci. 7: 3945-3952, 1987.

Arbas, E.A. and Calabrese, R.L. Slow oscillations of membrane potential in interneurons that control heartbeat in the medicinal leech. J. Neurosci. 7: 3953-3960, 1987.

Norris, B.J. and Calabrese, R.L. Identification of motor neurons that contain a FMRFamide-like peptide and the effects of FMRFamide on longitudinal muscle in the medicinal leech, Hirudo medicinalis. J. Comp. Neurol. 266: 95-111, 1987.

Calabrese, R.L., and Maranto, A.R. Cholinergic action on the heart of the leech, Hirudo Medicinalis. J. Experimental Biology 125: 205-224, 1986.

Carroll, L.S., Carrow, G.M., and Calabrese, R.L. Localization and release of FMRFamide-like immunoreactivity in the cerebral neuroendocrine system of Manduca sexta. J. Exp. Biol. 126: 1-14, 1986.

Li, C. and Calabrese, R.L. Evidence for proctolin-like substances in the central nervous system of the leech Hirudo medicinalis. J. Comp. Neurol. 232: 414-424, 1985.

Kuhlman, J.R., Li, C., and Calabrese, R.L. FMRFamide-like substances in the leech: I. Immunocytochemical localization. J. Neurosci. 5: 2301-2309, 1985.

Kuhlman, J.R., Li, C., and Calabrese, R.L. FMRFamide-like substances in the leech: II. Bioactivity on the heartbeat system. J. Neurosci. 5: 2310-2317, 1985.

Tolbert, L.P., and Calabrese, R.L. Anatomical analysis of contacts between identified neurons in the heartbeat system of the leech Hirudo medicinalis. Cell and Tissue Res. 242: 257-267, 1985.

Calabrese, R.L. and Arbas, E.A. Modulation of central and peripheral rhythmicity in the heartbeat system of the leech. In: Model Neural Networks and Behavior, pp. 69-85, A.I. Selverston, Ed., Plenum, NY, 1985.

Peterson, E.L. and Calabrese, R.L. (1982) Dynamic Analysis of a Rhythmic Neural Circuit in the Leech Hirudo medicinalis. J. Neurophysiol. 47:256-271.

Calabrese, R.L. (1980) Control of Multiple Impulse-Initiation Sites in a Leech Interneuron. J. Neurophysiol. 44:878-896.

Related Work

Zerbst-Boroffka, I., Bazin, B., and Wenning, A. (1997) Chloride Secretion Drives Urine Formation in Leech Nephridia. J Exp Biol.200:2217-2227.

Kennedy, D., McVittie, J., Calabrese, R., Fricke, R.A., Craelius, W. , and Chiapella, P. (1980) Inhibition of Mechanosensory Interneurons in the Crayfish. I. Presynaptic Inhibition From Giant Fibers. J. Neurophysiol. 43:1495-1509.

Stent, G.S., Thompson, W.J., and Calabrese, R.L. (1979) Neuron Control of Heartbeat in the Leech and in Some Invertebrates. Physiol. Rev. 59:101-136.

Thompson, W.J., and Stent, G.S. (1976) Neuron Control of heartbeat in the Medicinal leech. I. Generation of the Vascular Constriction Rhythm by Heart Motor Neurons. J Comp Physiol A.111:261-279.

Thompson, W.J., and Stent, G.S. (1976) Neuron Control of heartbeat in the Medicinal leech. II. Intersegmental Coordination of heart Motor Neuron Activity by Heart Interneurons. J Comp Physiol A.111:281-307.

Wiese, K., Calabrese, R.L., and Kennedy, D. (1976) Integration of Directional Mechanosensory Input by Crayfish Interneurons. J. Neurophysiol. 39:834-843.