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The Calabrese Lab
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A pair of HN4
neurons, one real and one simulated. If you have red-green
3D glasses, you can see the right cell in 3D.
(Cell viewer courtesy Robert
Cannon.) |
Our
lab studies the neural circuit that controls the heart of
the medicinal leech. We record the behavior of neurons
in this circuit with microelectrodes. Using voltage
clamp techniques, we isolate and characterize the individual
ionic currents which contribute to this behavior. We
study how the structure of these neurons affects their behavior
using dynamic imaging and selective dendritic laser ablation.
To understand how these currents and structures interact to
produce the behavior of the circuit, we simulate the ionic
currents and cell connectivity with realistic biophysical
models.
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